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Agency:    Department of Defense--Military
Bureau:    Research, Development, Test, and Evaluation
Account:    Research, development, test, and evaluation, Army (21-2040)
Certifying Official:    Deputy Comptroller Program/Budget
Contact Information:    http://WWW.DOD.GOV   703-697-5131
Computation Proteomics

1 recipient will receive $2,491,000. This is a continuing earmark.
Year Enacted: 2005
Description: The objective of this program is to develop tools that can be used to establish links between diseases and the structure and function of uncharacterized proteins; to understand cell metabolism and hence the mechanism of disease; and to accelerate the development of medical diagnostics and therapeutics. Computational Proteomics is the combination of chemistry, molecular biology, mathematics, computer science, and high performance computing to analyze the structure and function of proteins. The ultimate cause of the pathogenesis of many diseases is the protein misfolding. Protein folding is the process by which an unfolded polypeptide chain folds into a specific native and functional system. The research will focus on the following three major projects centered on various aspects of protein folding from theoretical to applied: 1) Exploring oxygen, nitric oxide, and carbon monoxide sensing of the globin-coupled sensors and protoglobins; 2) Molecular modeling, structure refinement of the dengue virus envelope protein, and in silico high throughput compound library screening for potential antiviral drugs; and 3) Protein Fold Recognition without Similarity.
Beneficiary/Recipient Amount ($K) Program Type Address
University of Hawaii $2,491 Public Educational Institution
Kihei, HI
Source: Appropriations Report Language - Conference
Reference: 108-622
Location: Line 29, Page 256
Citation Excerpt: Computation Proteomics

Last Modified: 16-Apr-2007

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